CJC-1295 is a peptide hormone that consists of 30 amino acids. In the human body, it functions as an analog of somatoliberin (a natural stimulator of growth hormone secretion). It works on the nucleus of the anterior pituitary gland and stimulates the secretion of growth hormone. The substance binds to GHRH receptors, which belong to the group of G-protein-coupled receptors. The CJC-1295 version of DAC (Drug Affinity Complex) binds to plasma proteins (albumin), which leads to a significant increase in the duration of action, due to the addition of lysine bound to the non-peptide DAC molecule (the version without DAC lasts 30 min).
GHRH GROUP
The abbreviation GHRH stands for Growth Hormone Releasing Hormone or Somatoliberin. Somatoliberin growth hormone releasing hormone, also known as somatotropin-releasing factor (GRF, GHRF) or somatocrinin, is a releasing hormone for growth hormone. It is 44 amino acid peptide hormone produced in the hypothalamus.
Mechanism of action
Somatoliberin is released from the nerve endings of these arcuate neurons and is transported to the anterior pituitary gland, where it stimulates the secretion of growth hormone by stimulating special receptors. GHRH is released in pulsatile manner, stimulating a similar pulsatile release of growth hormone. In addition, somatoliberin also directly contributes to slow wave sleep.
The action of somatoliberin is opposite to the action of somatostatin (a hormone that inhibits growth hormone). Somatostatin is released from the neurosecretory nerve endings of periventricular somatostatin neurons and transported to the anterior pituitary gland, where it inhibits growth hormone secretion. Somatostatin and somatoliberin are secreted in turn, causing a largerly pulsatile secretion of growth hormone.
Petides of the GHRH group work only when the level of somatostatin in the blood is low, or the activity of this hormone is minimal. And this happens only at a time when the level of growth in the blood rises either after natural releases or after injections. It is possible, but rather difficult, to determine when endogenous growth hormone will be released into the blood and, accordingly, to adjust the injection of the GHRH peptide to it. Therefore, in practice, the following method is used: the GHRH group stimulantis injected after the GHRH group stimulant. Less oftenafter an injection of exogenous somatotropin.
GHRH peptides increase the level of endogenous growth hormone and this is followed by the positive effects inherent in growth hormone. This hormone plays a key role in regulating body composition. An important property of growth hormone is its powerful lipolytic effect. The administration of growth hormone to people with its deficiency reduces body fat mass and significantly increases lean body mass. Growth hormone enhances lipolysis directly by reducing the action of a number of lipogenic enzymes and indirectly by increasing the production of other lipolytic hormones such as catecholamines and glucagon, as well as by increasing the expression of adipocyte adrenoreceptors. In general, these effects lead to an increase in the utilization of body fat.
Growth hormone plays an important role as anabolic agent in human skeletal muscle and tendon connective tissue, which provide the matrix for the transmission of force from individual muscle fibers to bone. Thus, reinforced connective tissuewill give a stronger and more resistant muscle tendon structure. Because of this reason that growth hormone is used by athletes to treat muscle and tendon injuries. Similarly, high GH level improve bone strenght both directly and indirectly by increasing intestinal calcium absorption and serum vitamin D concentrations.
Purpose to use
One of the most highly regarded effects of growth hormone is its effect on muscle anabolism. Growth hormone induces uptake of glucose and amino acids and stimulates protein synthesis, possibly using energy derived from its lipolytic activity. Growth hormone entails an increase in the level of IGF-1 protein, which in turn also has a number of positive effects synergistic with growth hormone, such as a burning fat, increasing muscle mass and strenghtening bone and tendon structures. Reasons to consider the use of GHRH peptides may include increased fat loss, improved muscle gain, reduced choleserol and triglyceride levels and improved healing after injuries. Some of the substances of the GHRH group have successfully migrated to the category of pharmacological drugs, but most are still undergoing research or clinical trials.
Advantages
No negative impact on blood sugar levels
Forms a natural pulsating character of growth hormone peaks in the blood
Effects
Sustained increase in groth hormone and IGF-q levels
Reduce visceral adipose tissue
Reducing total cholesterol and triglycerides in the blood&nbs
