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Description
Melanotan 2 is an innovative way to stimulate tanning and prevent the harmful effects of UV radiation. MT2 is a synthetic peptide analogue of the natural hormone malenocortin, which is the main factor that stimulates skin cells to produce melanin, the pigment that colors the skin and protects it from harmful UV rays. Melanotan 2 has a number of effects that are so attractive to people of different ages and genders: stimulation and increase in sexual desire (increased libido functions), and also reduces appetite, due to which you can get rid of excess weight.
There are two types of this peptide: Melanotan 1 and Melanotan 2. The first – Melanotan 1 is a very mild, with systematic effects, which is why it has already been approved for use in Italy. Melanotan 2 surprasses Melanotan 1 in terms of the effect on melanocortin receptors by several times, which makes it more effective for quick tanning, but the tan from Melanotan 2 is more pronounced.
Mechanism of action
Melanotan 2 is a hypothalamic hormone which belongs to the melanotropin family, a group of peptides that react with melanocortin receptors and has a wide range of effects on almost all tissue types. Other melanotropic hormones include ACTH and alpha melanocyte stimulating hormone (a-MSH). Melanotan 2 is an alpha-melanocyte- stimulating hormone analogue structurally modified t reduce enzymatic degradation and increase receptor binding. Initially, the properties of the hormone to cause sunburn and pigmentation were studied, but more recent studies have focused on its antioxidant properties, the effect on the displacement of physiological rhythms, and the possible usage of the drug as a therapy for erectile dysfunction. Melanotan 2 is a broad and powerful melanocortin system stimulant.
Melanocortin receptors are the main mechanism through which Melanotan 2 exerts its action. MCR or melanocortin receptors exist in various functions in the human body, as well as in many other organisms. All MCR’s consisting of various subtypes that perform various functions, make up the melanocortin system. The melanocortin system performs various functions in the body using different mechanisms based on a limited number of functional groups -it has profound systemic effects in central and peripheral interactions with other known neuropeptide systems (leptin, ghelin,insulin,etc.)
These functions include controlling energy balance,thyroid function, and insulin response. In addition, MCR’s play a major role in skin pigmentation and also affect reproductive function both physically and behaviorally. When combined with endogeneous opioids, they are able to modulate pain and nerve sensitivity, respond to inflamation, as well as exert neuroprotective effects (including resistance to oxidative stress), influence aggressiveness, and modulate circadian thythms, including arousal when waiting for food.
Effects of pigmentation
Pigmentation effects Melanotan 2 was initially studied for its effect in including skin pigmentation meditated by MK-1R receptor activity. The accidental discovery that Melanotan 2 also induces erections and increases libido in both men and women led to a wider study of Melanotan 2 for the treatment of sexual dysfunction, however, so far pigmentation is perhaps Melanotan 2’s best known quality. Melanotan 2 is told to be able to provide ‘therapeutic tan’ even in people at risk-melanin expression results in dark skin pigmentation associated with reduced risk of various skins cancers UV damage.
Erection and libido enhancement effects
In men and women Melanotan 2 is capable of causing acute sexual arousal, increased libido and (in men) increased erection parameters. Melanotan 2 is effective in the treatment of psychogenic erectile dysfunction as well as other types of erectile dysfunction. The erection enhancing properties of melanotan 2 are not limited to cases of psychogenic erectile dysfunction. Penile erection has been observed in men with various organic factors. The findings of increased sexual desire warrant further investigation into the effects of these centrally acting drugs on sexual desire disorders. Since Melanotan 2 works primarily in the brain, it is more effective in treating arousal disorders and causes genital arousal and increases libido in both women and men. However, various investigators have found that the erectile properties of Melanotan 2 are partly responsible for neuronal nitric oxide release.
Melanocortin system and obesity
The melanocortin system is a potential therapeutic target for reducing appetite and weight, increasing fatty acid oxidation, and treating diseases associated with obesity such as insulin resistance, diabetes and high blood pressure. Alpha-melanocyte stimulating hormone, whose analogue is Melanotan 2 is the main endogenous stimulator of the human melanocortin system. The alpha-MSH response in obesi