Ipamorelin 2mg

By its chemical structure, Ipamorelin is a synthetic pentapeptide. This feature classifies the ingredient to the growth hormone-releasing peptide (GHRP) family. Multiple studies approved its potent ability to stimulate the secretion of growth hormone (GH). Thus, the medication is recognized to be an effective treatment in both clinical and bodybuilding contexts. Its unique properties differentiate it from other GHRPs. However, these properties make it a popular choice for people who seek to enhance muscle mass and reduce body fat. Moreover, note that the component does not cause the common adverse effects associated with GH therapy.

Effects

1. Enhanced muscle mass. The component promotes muscle growth and increases strength and endurance. Moreover, it’s highly effective in counteracting muscle aging.
2. Improved recovery. The ingredient helps observe faster recovery after injuries and intense physical activities. Thus, it’s widely used after gym and fitness workouts.
3. Reduced body fat. The product contributes to weight loss. Due to its enhanced chemical properties, it speeds up fat loss while preserving muscle mass.
4. Anti-aging effects. The Ipamorelin supplement promotes bone cell formation, which reduces bone deterioration and improves overall bone health. The product is also effective in reducing aging impacts on muscles and enhancing physical performance.
5. Better cognitive function. The ingredient stimulates the release of growth hormones, which potentially improves memory and learning.
6. Boosted immune system. The component enhances immune function, which improves the body’s ability to respond to infections and inflammation.

Mechanism of Action

The effect of Ipamorelin is the same as that of Ghrelin. The latter is a natural hormone that stimulates the release of GH from the anterior pituitary gland. Ghrelin binds to the growth hormone secretagogue receptor (GHSR) in the pituitary and hypothalamus. This binding prompts the release of GH in a controlled manner. By imitating its action in cells, Ipamorelin comes to replace the hormone. Unlike other GHRPs such as GHRP-2 and GHRP-6, Ipamorelin stimulates GH release selectively. It means that the ingredient does not affect other hormones like cortisol and prolactin significantly. This selective action reduces the risk of side effects such as increased appetite, making Ipamorelin particularly suitable for fat loss and muscle building.

Control of Ghrelin Receptors

Ipamorelin establishes a connection with the receptors of the peptide hormone Ghrelin, which is called the growth hormone secretagogue receptor (GHS-R1a). These receptors are located in the pituitary gland. The drug enters the cell and initiates changes there that block cellular hunger, acting on the corresponding receptors.

Activation of G-Protein-Coupled Receptors

The connection of the component to GHS-R1a activates G-protein-coupled receptors (GPCRs). This process initiates the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol trisphosphate (IP3). The sequence of transformations is called the phospholipase C (PLC) pathway.

Calcium Release and Signal Transduction

As a result of the IP3 effect, calcium ions are released from the endoplasmic reticulum and enter the cytoplasm. This process leads to an increase in the volume of calcium inside the cells. With the help of somatotropic cells of the pituitary gland, the secretion of growth hormone is activated.

Growth Hormone Release

Growth hormone follows the direction of blood flow and initiates the renewal of new tissue cells, muscles, and cell parts. Thus, GH accelerates metabolism and triggers the growth of new tissues. Ipamorelin triggers a chain reaction of natural processes in the body that release growth hormone and send it to cells for speedy renewal.

GH Level Increase After Injection

Ipamorelin helps increase the concentration of growth hormone in cells. The therapeutic component is fast-acting; the effect is noticeable within 15 minutes after administration of the drug. The speed at which the renewal process starts at the cellular level depends on the volume of the injection administered. When growth hormone levels are achieved, the injection dosage is gradually reduced to the initial volume over two hours. It is recommended to follow the drug administration regimen — at least three times a day. With this support of natural renewal at the cellular level, growth hormone will be at the proper level.

Figure 1. Plasma GH levels versus time in swine following i.v. administration of Ipamorelin (●), GHRP-2 (□), GHRP-6 (x) and GHRH (△) using the most efficacious dose.

The reliability of the drug in terms of the degree of body rejuvenation is compared with exogenous injections of growth hormone. For example, from the point of view of activating and triggering the secretion of growth hormone, the dose ratio of 100 mcg of Ipamorelin is approximately equal to 1.5 IU of growth hormone.

Unique Actions of Ipamorelin via Ghrelin Receptors

Selective Activation

Ipamorelin selects and activates only GHS-R1a receptors. Other types of peptides receive sequential effects. At the same time, the drug reduces the likelihood of possible side effects. The selective work of Ipamorelin differs significantly from GH since it does not interact with hunger and satiety receptors. In this regard, the drug works exclusively with selected receptors.

Minimal Cortisol and Prolactin Release

Unlike other drugs, Ipamorelin has a minimal effect on the production of prolactin and cortisol, but in terms of triggering growth hormone, it is not inferior to popular medicinal products. Ipamorelin isolates the main receptors of hunger and satiety for control and initiates GH release. However, the drug does not affect the secretion of prolactin or the pituitary-hypothalamic-adrenal axis (HPA). As a result, conventional injections that trigger the growth hormone reduce the likelihood of side effects such as hyperprolactinemia and hypercortisolism.

No Appetite Stimulation

Ghrelin is a receptor that increases appetite, as it interacts with sensitive receptors in the hypothalamus. No increase in appetite is observed with the administration of Ipamorelin. The medical supplement affects exclusively renewal processes by increasing growth hormone but does not affect the feeling of hunger, selectively acting on the necessary receptors. If patients need to control weight, it is recommended to take ghrelin.

Cytoprotective Effects of Ipamorelin

Ipamorelin acts on the