Retatrutide 10mg

• Composition: Retatrutide 10 mg
• Category: Peptide
• Purpose: Weight loss
• Form: Vial with lyophilized powder + 1 ml ampoule of bacteriostatic water for reconstitution
• Administration: Subcutaneous injections

What is Retatrutide?

Retatrutide is an experimental peptide-based drug developed for weight loss and metabolic normalization. It acts through a triple mechanism by activating the GLP-1, GIP, and glucagon receptors — hormones that regulate appetite, blood sugar, and energy expenditure. This unique combination currently makes it one of the most promising new candidates for the treatment of obesity and metabolic disorders.

Who may benefit from Retatrutide?

✓ If you’re looking to lose weight and control your appetite without extreme diets or starvation — Retatrutide reduces appetite and prolongs the feeling of fullness, helping you eat less and comfortably shed excess weight.

✓ If you have insulin resistance, metabolic syndrome, or prediabetes — the drug enhances insulin sensitivity and supports blood sugar regulation.

✓ If you suffer from obesity and related conditions like high blood pressure, fatigue, or inflammation Retatrutide helps reduce the strain on internal organs and improves your metabolic background.

✓ If you’ve been diagnosed with type 2 diabetes — it can help better manage blood glucose, reduce food cravings, and serve as an additional therapeutic tool.

✓ If you aim to prevent fatty liver disease — Retatrutide may lower liver fat levels and reduce systemic inflammation.

How to take Retatrutide?

Retatrutide comes in a vial containing 10 mg of lyophilized powder. It must be reconstituted using the provided bacteriostatic water before use. You can read detailed instructions on how to prepare peptides and perform injections HERE.

Usage guidelines:

• Administer once a week, on the same day each week
• Before injecting, visually inspect the solution (it should be clear, with no particles or sediment)
• If nausea or weakness occurs, slow down the dose escalation or take a 1-week break

Dosage schedule:

To help the body adapt, start with a low dose — typically 2.5 mg per week — and gradually increase by 2.5 mg every 3–4 weeks. The target dose for strong clinical effects is 10–12 mg per week.

The most significant weight loss results were observed at these doses after 3–6 months of treatment.

Contraindications and precautions:

• Do not use if you have or have a family history of medullary thyroid cancer or MEN2 syndrome
• Use caution if you have pancreatitis, gallbladder disease, or thyroid conditions
• Do not combine with medications that slow gastrointestinal motility without medical advice

Possible side effects:

• Nausea (especially in the early weeks)
• Loss of appetite
• Bloating, gas, soft stool or constipation
• Fatigue, headache
• Rare: elevated pancreatic enzymes, abdominal pain (discontinue if severe pain occurs)

How Retatrutide works?

Retatrutide acts on three key hormonal receptors involved in food response and metabolic regulation: GLP-1, GIP, and the glucagon receptor. Their combined activation leads to appetite suppression, improved glucose control, and enhanced fat burning.

GLP-1

GLP-1 (glucagon-like peptide-1) is a hormone secreted by the gut after eating. It signals the brain that the body has received enough food, promoting early satiety and reducing hunger for several hours. It also slows gastric emptying, which prolongs the feeling of fullness.

Beyond appetite control, GLP-1 stimulates the pancreas to release insulin precisely when blood sugar rises — particularly important for people with insulin resistance. It also lowers glucagon secretion, a hormone that raises blood sugar. This dual mechanism helps restore proper metabolic balance in those with excess weight or metabolic dysfunction.

GIP

GIP (glucose-dependent insulinotropic peptide) is another hormone released after meals. It helps regulate blood sugar but in a different way than GLP-1. GIP amplifies the body’s insulin response, especially after consuming carbohydrates and fats.

It enhances insulin production and improves the ability of cells to absorb glucose, promoting its use for energy instead of leaving it in circulation. Persistent high blood sugar can overwork the pancreas, increase systemic inflammation, and accelerate fat accumulation — all of which raise diabetes risk. GIP also suppresses hepatic glucose production and may help regulate lipid metabolism by limiting fat storage.

Interestingly, GIP on its own has limited impact, but in combination with GLP-1, the results are significantly stronger — leading to greater blood sugar control and more effective weight loss.

Glucagon

Glucagon is a hormone that functions opposite to insulin. While insulin promotes nutrient storage after eating, glucagon is activated during fasting or low blood sugar. It triggers the mobilization of internal energy stores: breaking down glycogen in the liver, initiating lipolysis (fat breakdown), and stimulating glucose production from amino acids.

When glucagon receptors are artificially activated — as with Retatrutide — the body increases energy expenditure, even at rest. Lipolysis intensifies, so fat stored in adipose tissue is broken down and used as fuel.

Retatrutide vs Semaglutide vs Tirzepatide

Semaglutide, tirzepatide, and retatrutide all belong to the same drug class — they target hormones involved in appetite, glucose regulation, and energy balance. But they differ fundamentally in how they work, and studies show differences in clinical outcomes.

In short:

1. Semaglutide acts on one receptor (GLP-1)
2. Tirzepatide targets two (GLP-1 and GIP)
3. Retatrutide activates three (GLP-1, GIP, and glucagon)

Retatrutide is currently in Phase 3 clinical trials, with earlier phases already completed successfully. It has shown strong results in human trials without major side effects, making it a likely candidate for future approval as a new medical treatment.