MOTS-C 10 mg

What is MOTS-c?

MOTS-c is a peptide made up of 16 amino acids, first discovered in 2015 by researchers studying mitochondria, the “powerhouses” of our cells that produce energy. The main feature of MOTS-c is that this peptide is encoded by mitochondrial DNA, and not by nuclear DNA like most other peptides. The discovery of this peptide showed that mitochondria do more than just produce energy. They play a more complex role with multiple functions, from influencing human metabolism to participating in the aging process and maintaining overall health. Most of the MOTS-c studies have focused on the peptide’s potential to prevent and treat metabolic disorders such as diabetes, obesity, or insulin resistance. However, this peptide has attracted the attention of not only scientists and doctors. Athletes and biohackers have also become interested in the MOTS-c properties, such as the ability to improve physical performance, recovery after training, prolong youth, lose weight, and so on.

Perhaps one of the most interesting aspects of MOTS-c at the moment is its connection to aging. Research shows that MOTS-c levels naturally decline with age, which may contribute to a slower metabolism, decreased physical performance, and age-related health problems. More and more people are turning to MOTS-c to restore these levels, improve mitochondrial function, increase metabolic flexibility, and even delay certain aspects of aging.

Unfortunately, MOTS-c has not yet undergone full clinical trials on humans, but has shown impressive results in animal experiments. This has not deterred many people from deciding to experiment and try this peptide on themselves. Thanks to their experience we were able to collect and analyze data on its positive effects and side effects on humans. Most often, users note an increase in energy levels, accelerated recovery after training and exercise, as well as improved endurance and decreased appetite. Of course, without clinical studies it is difficult to judge the long-term effects of the drug on the human body. But the prognoses are reassuring and we have not noticed any complaints from users about any severe symptoms. So this drug has earned trust as a fairly safe drug with many benefits.

Many professional athletes use MOTS-c to keep their energy levels up during tough training, speed up recovery, and retain muscle while losing fat. For those interested in buying the MOTS-c peptide — in this description we have managed to collect and analyze a large amount of information to provide you with a more complete picture of MOTS-c.

Main effects and benefits of MOTS-c

 Improved insulin sensitivity. MOTS-c helps the body respond better to insulin by improving glucose uptake into cells. This promotes stable blood sugar levels and may lower the risk of type 2 diabetes.

Improved metabolic flexibility. This peptide helps the body use both sugar and fat as fuel, allowing it to produce energy in a variety of situations — during exercise, fasting, or on a low-calorie diet.

  Increased muscle endurance and performance. MOTS-c improves mitochondrial function, helping muscles produce more energy (ATP) during exercise. This helps increase endurance, reduce fatigue, and recover faster after exercise.

 Fat loss support. MOTS-c activates the fat-burning process by forcing the body to use stored fat as energy. Combined with improved insulin sensitivity, this helps reduce fat levels and improve body composition.

 Anti-aging properties. MOTS-c supports mitochondrial function, which can slow down the aging process. It helps prevent mitochondrial dysfunction, which is considered one of the main causes of age-related changes and related diseases.

 Protection against metabolic stress. MOTS-c helps cells cope with metabolic stress by improving energy production. This is especially important when the body requires more energy, such as during intense training or illness.

Mechanism of action

To understand how MOTS-c works, it is important to first understand mitochondria. Mitochondria are tiny structures found inside almost all cells in the body. They generate energy by breaking down nutrients and converting them into ATP, the main fuel for cells. Think of mitochondria as the power plants of cells — they keep everything running by providing the energy cells need to perform their functions.

Over time, mitochondria can become less efficient due to factors such as aging, stress, and poor diet. This inefficiency leads to reduced energy production and increased oxidative stress, which can cause cellular damage. MOTS-c helps counteract this by improving mitochondrial function.

How MOTS-c works?

MOTS-c is a special peptide because, unlike most proteins and peptides, it is encoded not in the cell nucleus, but in the mitochondria. They have their own DNA (mtDNA), which is passed down only from the mother and which is different from the DNA inside the nucleus of the cell (nuclear DNA). When MOTS-c is produced in the mitochondria, it does not stay there but moves around the cell, transmitting signals and helping the body use energy more efficiently and cope with stress. In essence, it is a built-in mechanism in our cells that keeps them functioning and helps the body adapt to stress.

Here are the key ways MOTS-c works:

• Activating AMPK (Energy sensor). Our body has a special enzyme AMPK (AMP-activated protein kinase) that monitors the energy level in cells. If energy becomes low, it switches on the economy mode and at the same time helps the body to get more fuel. MOTS-c activates this process, which leads to:
  • More glucose in cells — sugar from the blood enters the cells faster and is converted into energy.
  • Fats are burned faster — the body begins to use fat more actively as a source of energy.

Thanks to this, cells do not experience a lack of energy even during stress, physical activity or lack of food.

• Modulating the folate cycle. MOTS-c affects the folate cycle, an important process that helps cells create the building blocks of DNA and RNA (nucleotides). These substances are necessary for cell renewal, repair, and normal functioning of the body.

When the body is under stress, such as intense exercise or a lack of calories, cells require more nucleotides to repair damage and maintain their function. MOTS-c helps the folate cycle work more efficiently so that cells can:

• Recover faster from stress.
• Create new cells for tissue renewal.
• Protect DNA from damage.

Thus, MOTS-c helps the body adapt to stress, maintain energy and keep cells healthy.

• Stimulating mitochondrial biogenesis. Inside every cell there are mitochondria, small “power plants” that produce ATP (the main source of energy). The more mitochondria in a cell, the more energy it can produce. MOTS-c helps the body create new mitochondria. This process is called mitochondrial biogenesis. How it works:
  • MOTS-c triggers the production of mitochondrial proteins and DNA, which leads to the formation of new mitochondria.
  • In muscle cells, which need a lot of energy, this is especially important for endurance and recovery after exercise.
  • More mitochondria means less fatigue, better energy use, and faster strength gains.
• Reducing inflammation. Long-term inflammation is one of the causes of many health problems, such as diabetes, obesity and heart disease. MOTS-c helps the body regulate the inflammatory process, reducing the harmful effects on tissues. How this process works:
  • MOTS-c reduces the level of inflammatory molecules (TNF-α, IL-6, IL-1β), which cause chronic inflammation.
  • Increases the amount of anti-inflammatory substances (IL-10, TGF-β), which help the body calm inflammation and restore damaged tissues.
  • Thanks to this balance, MOTS-c protects cells from destruction, maintains a healthy metabolism and helps to recover faster from stress, injuries and age-related changes.

• Adaptive gene regulation. Cells are constantly adapting to changes in the body, such as a lack of nutrients or high energy demand. MOTS-c regulates the activity of certain genes, helping cells adapt to such conditions more quickly.
  • MOTS-c affects the activity of genes that control metabolism, cell growth, and stress response.
  • It interacts with special proteins (transcription factors) that turn on or off the right genes in response to external conditions.
  • This helps cells use resources sparingly, maintain energy balance, and protect themselves from damage in difficult conditions.

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While MOTS-c shows a lot of promise in improving energy, reducing inflammation, and supporting recovery, we still don’t know everything about it. Most studies have been done in labs or on animals, and we don’t yet fully understand its long-term effects or potential risks.

What we do know is exciting: it helps mitochondria work better, boosts energy, and protects against stress. But as with any new discovery, more research is needed to see how safe and effective it is over time.

Recent researches of MOTS-c

Over the past few years, there have been many studies and experiments on the effects of MOTS-c on living organisms and on various factors, ranging from metabolic health to aging. Below, we will look at a couple of recent articles that have documented the positive effects of this peptide.

 MOTS-c and metabolic disorders.

In 2021, a study published in the scientific journal Nature Communications (https://doi.org/10.1038/s41467-020-20790-0) examined the effects of MOTS-c on exercise performance and muscle homeostasis in aging mice. Increasing MOTS-c levels improved endurance and muscle function in aged mice. Although the study was conducted in aging models, the results indicate that under stress, MOTS-c levels are reduced, and increasing them leads to restoration of metabolic functions that stress can impair.

Key result: Mice treated with MOTS-c demonstrated enhanced endurance and muscle function compared to untreated controls.

Anti-aging effects.

A 2022 study (https://doi.org/10.3390/ijms231911991) examined the role of MOTS-c in aging by measuring its effects on mitochondrial function in aged mice. The results showed that after increasing MOTS-c levels mitochondrial efficiency started to restore, markers of oxidative stress restored, and the lifespan of mice increased by ~10%.

Key result: Treated mice have better physical performance and endurance compared to untreated older mice.

 MOTS-c levels in type 1 diabetes patients.

A 2023 study published in Diabetes & Metabolism Journal (https://doi.org/10.4093/dmj.2022.0333) examined MOTS-c levels in patients with type 1 diabetes compared to healthy individuals. The study found that MOTS-c levels were significantly lower in type 1 diabetes patients, suggesting a potential role of MOTS-c in autoimmune diabetes.

Key result: Lower MOTS-c levels are associated with poor glycemic control and higher HbA1c levels.

 Plasma MOTS-c levels in obese children and adolescents.

A study in the journal European Society for Paediatric Endocrinology (ESPE) (https://doi.org/10.1111/pedi.12685) explored plasma MOTS-c levels in obese Chinese male children and adolescents aged 5–14 years. The researchers observed a significant 20.3% reduction in plasma MOTS-c levels in obese participants compared to healthy controls.

Key results:

• Participants with elevated BMI had low levels of MOTS-c, suggesting a link between the low level of peptide and obesity.
• The study discusses the potential of MOTS-c in the treatment of obesity and the prevention of type 2 diabetes

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You may have noticed that there was no mention of studies examining the effects of MOTS-c on humans. Yes, that’s right, there have been no clinical trials in which this peptide has been administered to humans. All available experimental work has been conducted on animals. These studies have revealed very interesting and statistically significant effects, but mouse tests still don’t give us a complete picture of how the peptide affects the human body. However, there are studies that have measured MOTS-c levels in the blood of humans and analyzed the correlation between the peptide level and such indicators as obesity, insulin sensitivity and other metabolic disorders. These studies have made it clear that low MOTS-c levels are indeed associated with aging and other negative factors such as diabetes and obesity.

Why are there no clinical trials on humans yet? MOTS-c is a very new discovery in the field of medicine, and clinical trials on people are always a very long and expensive process, so not enough time has passed yet. Currently, a clinical trial is underway on the peptide CB4211, which is a synthetic analogue of MOTS-c. CB4211 is being tested in humans for the treatment of non-alcoholic steatohepatitis (NASH) and obesity, so it is possible that we will soon see this analogue on pharmacy shelves. The research is still in progress, but we really hope that soon we will be able to get more official scientific data on the long-term effect of MOTS-c and its analogue, so that we can have a more complete picture of its effects and risks.

Despite the promising potential, we still want to warn you that the long-term risks of the drug have not yet been studied, so you should always be aware of the risks. That’s why we encourage you to approach its use with awareness and caution.

Uses and applications of MOTC-s

In this section we would like to collect all the information about the purposes of using MOTS-c, as well as the effects that have been noted by many users, for those who are thinking about buying and trying MOTS-c peptide on themselves. Since we do not have enough information from scientific sources for a complete picture, we decided to collect information from all possible sources — familiar people, forums, educational videos, user reviews — to analyze and identify the effects that most people note. The drug has become increasingly popular in recent years; many people were ready to experiment on themselves. This allowed us to do this analysis, tell you about the effects of the drug, and also warn you about possible side effects.

Metabolic health and weight management

People talk a lot about MOTS-c, especially when it comes to metabolism. The idea is that it helps mitochondria work better, which in turn makes it easier for the body to handle sugar and fat. Some users who’ve tried it usually swear by a couple of key benefits:

• More stable blood sugar levels. Some users claim MOTS-c helps keep their glucose levels in check and makes their bodies respond better to insulin. That could be useful for those struggling with insulin resistance, prediabetes, or even type 2 diabetes.
• Weight control without constant struggle. Since MOTS-c supposedly helps the body switch between burning sugar and fat more efficiently, many find that it makes shedding pounds (or keeping them off) a little easier, especially if you’re also watching your diet and cutting back on calories.

Athletic performance and recovery

Fitness enthusiasts and athletes have become interested in MOTS-c because of its potential impact on sports performance and recovery. By optimizing mitochondrial function, it may help:

• Fight fatigue. MOTS-c might help people push through longer workouts by making energy production more effective, which is great for endurance or intense training.
• Speed up recovery. Some people have noticed less soreness and quicker recovery times after exercise, possibly because MOTS-c helps with cell stress and tissue repair.

Anti-aging and longevity

A lot of excitement around MOTS-c comes from its potential to slow down the aging process. As we get older, our mitochondria don’t work as well, oxidative stress builds up, and overall energy levels drop. Some believe MOTS-c could help turn back the clock by:

• Keeping mitochondria in top shape. It’s thought to boost mitochondrial protein and DNA production, helping these tiny energy factories stay efficient as we age.
• Taming inflammation. Some reports suggest it might help calm chronic inflammation, which is often linked to aging and long-term health issues.
• Boosting energy and sharpness. Many users say they feel more mentally clear, physically strong, and just overall “better” when taking MOTS-c.

Chronic disease management

MOTS-c is not an officially recognized treatment for any disease, but that hasn’t stopped people from looking into how it might support long-term health. Some believe it may play a role in managing certain conditions by:

• Keeping the heart and blood vessels in check. Since MOTS-c is thought to boost energy production and reduce oxidative stress, some think it could help support cardiovascular health and keep circulation running smoothly.
• Protecting the brain. There’s speculation that it might help fight age-related cognitive decline by keeping mitochondria healthy and lowering inflammation, which could be useful for long-term brain function.
• Helping with metabolic issues. Because of its potential role in regulating metabolism, some believe MOTS-c may help with things like obesity, fatty liver disease, or metabolic syndrome — all conditions tied to how the body processes energy.

Dealing with stress and building resilience

Life throws a lot at us: long workdays, intense workouts, lack of sleep, and just everyday stress. Some people believe MOTS-c might help the body handle pressure better by:

• Keeping energy up during hectic times. If you are constantly on the move, both mentally or physically, MOTS-c can help you feel more resilient and less drained by stress.
• Bouncing back from illness. Some users say it helps them recover from illnesses, especially conditions that drain energy and slow metabolism.

Dosage, administration, and precautions

How to use MOTS-c and the most common usage protocols

There are currently no official guidelines or scientifically validated dosing protocols for MOTS-c. Individual responses can vary greatly, so it’s important to assess your own body’s response. Since everyone’s body reacts differently, much of what we know comes from trial and error shared by people who have experimented with it themselves. If you’re thinking about trying it, the safest bet is to start small and see how your body responds before making any adjustments.

Here are some of the most commonly followed protocols by people using this peptide:

Protocols with less frequent dosing:

• Dose: 5 mg of MOTC-s.
• Frequency: Every 5 days.

Duration: Typically, 20 days.

Protocols with moderate-frequency dosing:

• Dose: 10 mg of MOTC-s.
• Frequency: Three times a week (e.g., Monday, Wednesday, Friday).

Step-up protocols:

• Phase 1: 2.5 mg three times per week for the first 4 weeks.
• Phase 2: 5 mg once per week for the next 4 weeks.

Administration guidelines

• Injection method: administer MOTS-c via subcutaneous injection (under the skin).
• Preparation: before use, reconstitute the peptide with bacteriostatic water.
• Sterility: use proper injection techniques and sterile equipment to avoid infections.

Here you can check instructions about how to prepare and inject peptides.

How long?

Typical cycles last 4 to 6 weeks, but between cycles it is worth taking a break of at least 2–4 weeks.

We do not recommend taking the drug for longer than 8 weeks, as the chance of experiencing side effects increases, and the consequences of such long-term use are not fully known.

Precautions

• Start slowly. Always begin with a minimal dose to monitor your body’s reaction. Adjust only if you do not feel any effects.
• Injection safety. Be sure to sterilize the injection site and use only disposable syringes to avoid the risk of infection.
• Research limitations. Keep in mind that MOTS-c has not been fully studied for its long-term effects, especially when taken long-term, so monitor your feelings and do not exceed the dosage.
• Possible impact on folate metabolism. MOTS-c may affect the folate cycle and slowly lower folate (5-MTHF) levels inside cells over time. This isn’t fully proven yet, but it’s something to consider with long-term use. Low 5-MTHF could make it harder for the body to repair DNA, increase oxidative stress, and affect methylation. This can cause fatigue, trouble thinking clearly, or, over time, raise homocysteine levels, which can pose a risk to heart health.
• Monitor your health. Listen to your body during the cycle. If suddenly you feel any strange symptoms or discomfort — it is advisable to stop taking it. If you have any concerns or any problems have arisen, you can always write to our medical expert and get a free consultation! For consultation, contact us via Telegram.

Side effects

While MOTS-c is generally well-tolerated by most users, some side effects have been reported, especially during experimentation with higher doses. Below are the potential side effects to be aware of:

• injection site reactions (redness, swelling, or irritation);
• mild fatigue;
• sleep disturbances;
• changes in appetite;
• temporary digestive issues;
• headache;
• dizziness;
• allergic reactions;
• hormonal imbalances (since MOTS-c affects energy metabolism and mitochondrial function, there’s a possibility it could indirectly influence hormone levels, especially those related to stress (e.g., cortisol) or metabolism (e.g., insulin));
• electrolyte imbalances;
• potential risk of nutrient imbalances (as mentioned earlier, prolonged use might impact the folate cycle, but it could also indirectly affect other nutrient balances, like B vitamins or magnesium);
• mood changes.

If you feel some serious side effects or experience anything unusual — you can contact our medical experts via Telegram. We will help you understand what is happening and navigate you in resolving any issue. Consultations are free, we truly care about your health and safety!

How to store MOTS-c

• Keep out of reach of children.
• Store in the fridge at 2-8°C (36–46°F) in a dry place, away from direct sunlight.
• Once mixed, use within 7–10 days and don’t exceed the expiration date.

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Why Choose Us?

We are Driada Medical Store, and we want to create something truly valuable and special. Our goal is to help and educate people who, like us once, decided to embark on the path of improvement and achieving new goals. In addition to producing quality products, we would love to bring our customers together and create the largest community where we can communicate, educate ourselves, share opinions and support each other. We would like to tell you a little about our key features, which we have been working towards for a long time:

 Large selection of products.

 We try very hard to provide all the necessary products to achieve different goals. From anabolic drugs and medications that are necessary to prevent health problems to various new products that will be of interest not only to the sports audience, but also to biohackers and just people who want to improve their appearance, endurance, prolong youth, and generally improve the quality of life. We always try to offer the most affordable prices. The cost of MOTS-c can be very different on the market, but we offer you the most favorable price.

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Our support is always ready to help you, and you can contact us in any way convenient for you — via chat on our website, email, or telegram. We are constantly working to improve the quality of service, and no request will be left without attention. We are ready to answer any questions you may have and solve any of your problems.

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Join our family, where like-minded people communicate, support each other, help, and share their successes! We created the PEDs Father community not only to unite people with similar goals, but also to share the knowledge of our large team, educate our clients and collect all the necessary information in one place. Finding reliable information can be difficult, you have to study different sources, where you cannot always get truthful and safe information, so we have combined the efforts of many professionals in this field to simplify your task. Also once a week we hold a vote for the product of the week, which will be sold at a 50% discount for the entire next week. This is a great opportunity to buy the MOTS-c peptide at a sale price.

FAQ

Does MOTS-c work for weight loss?

Yes, this is one of the most common reasons why people want to try MOTS-c. The peptide has the ability to reduce weight by improving metabolic functions, without a large risk of side effects.

Does MOTS-c build muscle?

No, MOTS-c is not an anabolic agent and does not directly help to build muscle tissue. However, this drug can help you improve your workout performance and reduce recovery time, which will definitely will have a positive effect on your results.

Is MOTS-c safe to take?

There are not enough scientific and clinical studies on humans to be sure that the drug is safe for long-term use. But analyzing the reviews of people who have taken this drug, it seems that this peptide is quite safe if you follow the dosages and do not exceed the period of use.