- Stock: Out Of Stock
- Composition: Ezetimibe 10 mg
- Category: Cycle support (cholesterol absorption inhibitor)
- Purpose: Supports lipid profile, lowers LDL levels, and protects the cardiovascular system
- Form: Tablets
- Administration: Oral
What is Ezetimibe?
Ezetimibe is a modern drug that helps reduce total cholesterol, LDL, and the risk of cardiovascular disease. Unlike statins, which act on the liver, ezetimibe has a different mechanism of action: it inhibits the absorption of cholesterol from food and bile, preventing it from entering the bloodstream. Due to this different mechanism of action, ezetimibe combines well with statins, significantly enhancing its effectiveness.
This drug is especially suitable for athletes using PEDs, particularly AAS, which increase LDL and decrease HDL, leading to the risk of cardiovascular complications so common among professional athletes.
Main effects of Ezetimibe
📉 Reduction of LDL levels
🔽 Moderate reduction in total cholesterol and triglycerides
🛡️ Increased effectiveness in maintaining HDL levels when combined with statins (e.g., Pitavastatin)
🍃 Less stress on the liver than statin monotherapy
🫀 Additional cardiovascular protection for athletes using PEDs
How to take Ezetimibe?
Dosage, schedule, and combination with statins
| Type | Dosage | Duration |
|---|---|---|
| Ezetimibe monotherapy | 10 mg once daily | Minimum 4–6 weeks, can be used long-term |
| Combination with Pitavostatin | Ezetimibe 10 mg + Pitavostatin 1–4 mg/day | The course usually lasts from 3 to 12 months |
When using AAS, the same dosages are used throughout the AAS cycle, plus an additional 4-6 weeks afterward to maintain the lipid profile and protect the cardiovascular system.
Usually, the dose is fixed (10 mg/day), and no increase is required—effectiveness is achieved with the standard dosage.
Continuation or adjustment of therapy is recommended based on monitoring tests: cholesterol levels (LDL, HDL, total), triglycerides, and liver function tests (ALT, AST).
Precautions
- Avoid concomitant use with cyclosporine (increased concentrations).
- Monitor liver enzymes (ALT, AST) during combination therapy with statins.
- Use with caution in patients with liver disease.
Side effects
- Mild gastrointestinal disturbances (diarrhea, abdominal pain)
- Headaches.
- Fatigue.
- When combined with statins, the risk of muscle pain is higher than with monotherapy.
How to store?
- Store in a dry place at temperatures below 25°C, away from sunlight.
- Use before the expiration date.
- Keep out of reach of children.
How does Ezetimibe work?
Ezetemibe works in the small intestine, where most of the absorption of dietary cholesterol (found in the food you eat) and bile cholesterol (cholesterol secreted by the liver in bile to digest fats) occurs. The drug targets a special transporter protein, NPC1L1 (Niemann-Pick C1-like 1), which is found on the surface of intestinal cells. This protein acts as a passageway through which cholesterol enters the bloodstream. Ezetemibe closes this passageway, and instead of entering the bloodstream, cholesterol is naturally eliminated from the intestines. (Altmann et al., 2004).
When cholesterol levels decrease, the liver receives a signal that its reserves are insufficient. As a result, the liver responds by increasing the number of LDL receptors, which transport cholesterol from the blood to the liver (Sudhop et al., 2002). As a result, LDL levels in the blood decrease.
The more LDL particles are utilized by the liver, the less "bad" cholesterol remains to be deposited on the vessel walls.
When combined with statins, the effect is enhanced. Combining Ezetimibe with statins significantly reduces the risk of atoresclerosis and improves its prevention (Badarin et al., 2009, Cannon et al., 2015).
👉 We highly recommend combined use for athletes, especially those taking AAS. AAS shift lipid balance toward increased LDL and decreased HDL, which increases stress on the heart and the risk of cardiovascular disease, which is the most common cause of death in athletes taking these medications.
FAQ
Can Ezetimibe be taken with statins like Pitavastatin, Atorvastatin or Rosuvastatin?
Yes, Ezetemibe is often used in combination therapy with other statins to more effectively lower cholesterol and LDL levels.
Does Ezetimibe affect exercise or muscle recovery?
The drug does not have a negative effect on muscles and their recovery.
Does Ezetimibe reduce the absorption of vitamins or nutrients?
At high doses, the medication may slightly reduce the absorption of fat-soluble vitamins such as A, D, E, and K.