Category: Cycle support, performance enhancing drug (beta-blocker)
Purpose: Blood pressure control, cardiovascular support, improving performance in sports requiring precision and accuracy.
Form: Tablets
Administration: Oral
What is Nebivolol?
Nebivolol is a modern medication belonging to the beta-blocker class. It lowers blood pressure, promotes a calm and regular heart rhythm, and helps blood vessels relax by stimulating nitric oxide (NO) production.
For athletes, nebivolol will help managing cardiovascular stress and the risks associated with lifestyle, high-intensity training, and PEDs use.
Athletes also buy nebivolol to improve their precision (it reduces hand tremors and calms the central nervous system), in sports such as billiards, archery, tactical shooting, and more.
Main effects of Nebivolol
🧘♂️ Nebivolol lowers high blood pressure and makes it more even, without fluctuations.
🔽 Slows the heart rate, reducing the strain on the heart.
🩸 Dilates blood vessels and improves blood flow.
🩺 Reduces the negative effects on the heart from intense exercise or taking PEDs.
🛡️ Reduces the risk of complications from high blood pressure.
✋ Eliminates hand tremors and stabilizes the central nervous system.
🍬 Does not impair lipid and carbohydrate metabolism, improves insulin sensitivity.
🍃 Has antioxidant and anti-inflammatory effects.
🫀 Helps reduce left ventricular wall thickening (especially in the early stages of heart problems due to AAS use).
How to take Nebivolol?
How much and when?
Standard dosage: 5 mg
For cardiovascular support while taking PEDs:
you can start with 1.25-2.5 mg for risk prevention
2.5-5 mg for moderate increase of blood pressure
if blood pressure is high, you can increase up to 10 mg.
Take once daily at the same time, with or without food.
When taking PEDs, it is recommended to take it throughout the entire cycle and for 2-4 weeks after.
Do not suddenly stop taking Nebivolol! Gradually reduce the dosage, otherwise you may experience blood pressure spikes and heart problems.
Please note!
Don't stop taking it abruptly! Reduce the dosage gradually.
Check your blood pressure and pulse rate regularly to adjust dosages and avoid problems.
Do not take with other medications that affect heart rhythm (other beta blockers, some antidepressants, stimulants, etc.)
Monitor your condition - extreme fatigue, shortness of breath, swelling are signs that it may be necessary to adjust the dosage.
If your blood pressure is too low, your heart rate is slow, and you feel worse, you should gradually reduce your dosage and, if necessary, discontinue the medication.
Don't buy nebivolol from untrusted sellers. In our store, you'll find Nebivolol 5mg at a reasonable price and pharmaceutical quality.
Possible side effects
Dizziness and fatigue
Slow heart rate (bradycardia)
Decreased blood pressure, even to the point of hypotension
Shortness of breath during exertion or chest tightness
Cold extremities
Possible sleep disturbances or mild depression
Headache
Nausea, indigestion
Increased sweating
Erectile dysfunction or decreased libido
Allergic reactions (skin rash, itching)
How to store?
Store in a dry place at room temperature
Keep out of direct sunlight
Keep out of reach of children
How does Nebivolol work?
β1-receptor blockade
β1-adrenergic receptors are located in the heart and kidneys. Normally, when they are stimulated by norepinephrine (the stress and activity hormone), the heart begins to beat faster and more forcefully, and the kidneys secrete more renin, a substance that increases blood pressure. Nebivolol selectively blocks these receptors: the heart beats more calmly, the rhythm becomes more regular, and renin levels decrease. As a result, blood pressure stabilizes, and the workload on the heart decreases (Fongemie & Felix, 2015, Münzel & Gori, 2009).
🏹 This mechanism of action also helps to get rid of hand tremors and improve the precision and control of fine motor skills.
Activation of β3 receptors
In addition to blocking β1-receptors, nebivolol acts on β3-adrenergic receptors (Bordicchia et al., 2014). These receptors are found in fat tissue and are associated with lipolysis—the breakdown of fats. Their stimulation helps the body more efficiently use fats as energy and improves glucose and lipid metabolism. (Manrique et al., 2009). For athletes, this means better energy utilization and a lower risk of metabolic breakdowns during exercise and when taking PEDs.
🩺 Anabolic steroid use disrupts fat and carbohydrate metabolism (increases bad cholesterol, decreases insulin sensitivity), and many other beta-blockers make the situation worse. Due to the mechanism of action described above, Nebivolol, on the contrary, does not disrupt metabolism and even slightly improves insulin sensitivity.
Nitric oxide (NO) production
The endothelium is the inner lining of blood vessels. Nebivolol stimulates endothelial cells to produce more nitric oxide (NO) (Maffei & Lembo, 2009). NO acts as a signal for vasodilation: the vascular wall relaxes, blood flow improves, and resistance decreases. This prevents the heart from working too hard, distributing the load evenly and making it safer. (Diehl et al., 2016).
💪 Anabolic steroids increase oxidative stress, which damages blood vessels, the heart, and other tissues. Oxygen delivery to tissues is impaired. Increased nitric oxide (NO) production helps improve oxygen and nutrient delivery to muscles for effective growth and recovery.
Impact on hormonal systems
Renin and aldosterone are hormones that regulate water and salt balance. When they are too much, the body retains fluid, blood pressure rises, the heart is forced to work harder, and over time is developing hypertrophy (thickening of the heart walls) (Nesarhosseini et al., 2019). Nebivolol reduces renin and aldosterone levels, helping to maintain normal water-salt balance and prevent harmful changes in the structure of the heart. (Chan et al., 1992).
🫀When taking anabolic steroids, the heart has a harder time coping and over time, the heart walls can thicken. Nebivolol will help reduce the load on the heart and prevent thickening of the heart walls in the early stages.
FAQ
Does Nebivolol affect exercise performance or muscle recovery?
The drug has almost no direct effect on endurance and strength, but it can even improve your performance due to improved blood circulation.
Does Nebivolol affect libido or erectile function?
Unlike other beta blockers, Nebivolol may even improve erectile function due to nitric oxide activity.
Can Nebivolol help with anxiety or stress-related heart palpitations?
Yes, this medication can calm stress-related heart palpitations and lower blood pressure, and the nebivolol 5 mg tablet price makes it a cost-effective choice for daily management.
