Sibutramine — Appetite Suppressant for Weight Loss

What is Sibutramine

Sibutramine is a medication that was used as an appetite suppressant for weight loss. It works by increasing levels of certain neurotransmitters in the brain that influence hunger and satiety. It has been withdrawn from many markets due to safety concerns, and unsupervised use can be risky.

Sibutramine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine, which may increase feelings of fullness and reduce appetite. It is often discussed by people who struggle with overeating or emotional eating, but medical supervision is important because of potential cardiovascular and psychiatric risks.

How does Sibutramine work?

Sibutramine inhibits the reuptake of neurotransmitters such as serotonin, norepinephrine, and dopamine, which plays a role in appetite regulation. By increasing the availability of these neurotransmitters in the brain, it can increase satiety and reduce hunger. Any weight-loss support should be considered only in a clinical context alongside diet, activity, and risk assessment.

Who might discuss it with a clinician?

• ✔ People struggling with appetite control or overeating who want evidence-based options.
• ✔ Individuals seeking weight-loss support where a clinician can evaluate risks, contraindications, and safer alternatives.

Safety notes (important)

Sibutramine has significant safety concerns and is restricted or unavailable in many countries. It can raise heart rate and blood pressure, and may increase cardiovascular risk in susceptible individuals.

• Potential adverse effects include increased heart rate/blood pressure, headache, dizziness, dry mouth, constipation, insomnia, anxiety, and mood changes.
• Do not self-medicate. If you have used it, consider medical evaluation and appropriate monitoring, especially if you have cardiovascular symptoms.