Drostanolone propionate Vial

What is Drostanolone propionate

Drostanolone propionate is a synthetic anabolic-androgenic compound derived from dihydrotestosterone (DHT).

Initially developed in the 1960s, it was once used in medical practice for treating hormone-dependent breast cancer in women, but today it is mainly known for its application in the field of sports physiology and bodybuilding.

The compound is valued for its ability to enhance muscle hardness and definition without promoting fluid retention.

Its non-aromatizing nature prevents conversion to estrogen, making it a preferred option during cutting cycles when athletes aim to achieve a lean, dry physique with visible muscle separation.

Main effects of Drostanolone propionate

💪 Increases muscle density and tone, giving a defined, sculpted appearance

🔥 Enhances fat metabolism and accelerates lipolysis

⚡ Promotes strength and endurance without excessive weight gain

🩸 Improves vascularity and oxygen utilization

🧬 Supports nitrogen retention and protein synthesis

💦 Prevents estrogen-related side effects such as water retention or gynecomastia

How to take Drostanolone propionate

Administration

• Route: intramuscular injection using an oil-based solution
• Frequency: typically every other day due to the short half-life of the propionate ester
• Use sterile equipment and proper technique to prevent local irritation or infection
• The injection site should be alternated regularly

Dosage

For men, the standard dosage ranges from 300 to 500 mg per week, divided into injections every 48 hours.

Advanced users may increase up to 600 mg per week, depending on tolerance and goals.

For women, the range is typically 50 to 150 mg per week, with careful monitoring to avoid virilization symptoms.

Cycle duration usually spans 6–12 weeks, depending on the athlete’s program and compound combination.

Precautions

• Regularly monitor liver enzymes, lipid profile, and blood pressure
• Avoid combining with other DHT derivatives to reduce androgenic strain
• For prolonged cycles, implement post-cycle therapy to restore endogenous testosterone production
• Combine with testosterone esters in balanced proportions for synergistic effects and hormonal stability

Possible side effects

• Acne, oily skin, or hair thinning in androgen-sensitive individuals
• Temporary suppression of natural testosterone synthesis
• Mild fluctuations in mood or aggression
• Alterations in lipid levels (lower HDL, higher LDL)
• Virilization effects in women at higher doses (voice deepening, body hair growth)

Contraindications

• Androgen-dependent tumors (prostate or breast carcinoma)
• Severe hepatic, renal, or cardiovascular impairment
• Pregnancy or breastfeeding
• Hypersensitivity to drostanolone or formulation components

How to store

• Keep at 15–25 °C, away from moisture and direct sunlight
• Do not refrigerate or freeze
• Store the vial upright, tightly closed, and out of reach of children

How does Drostanolone propionate work

Once injected, drostanolone propionate undergoes hydrolysis, releasing the active hormone into circulation.

It binds to androgen receptors located in skeletal muscle and adipose tissue, initiating transcriptional mechanisms responsible for muscle growth, fat metabolism, and tissue regeneration.

Mechanism of action

• Androgen receptor activation: Enhances protein synthesis and nitrogen balance, promoting steady muscle hypertrophy.
• Anti-estrogenic activity: Competes with estrogen at receptor sites and reduces aromatase expression, lowering overall estrogen activity in the body.
• Lipolytic stimulation: Increases the activity of hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), accelerating fat breakdown.
• Anti-catabolic protection: Suppresses glucocorticoid hormones such as cortisol, preserving muscle tissue during calorie restriction.
• Nitrogen retention: Maintains a favorable anabolic environment for protein synthesis and muscle recovery.

Pharmacological profile

Drostanolone propionate has a half-life of approximately two days, ensuring rapid onset and sustained but manageable activity.

The compound’s balance of anabolic and androgenic properties makes it a preferred choice for cycles focused on muscle definition and body recomposition.

It produces a characteristic “dry” muscular look — firm, dense, and visually defined — while supporting performance and endurance without significant weight gain.