THE COMPOSITION OF THE CYCLE

We have divided everything into two main categories. The Main PEDs category are those substances that make the main effect and their choice will depend on your goals - Bulk, Cutting, Endurance or other possible goals. 

The second category is substances that reduce the risk of side effects. This group of drugs is no less important than the anabolic steroids themselves because in some cases the side effects that you get, may outweigh all the positive effects from PEDs. We have divided them into subgroups that are associated with the most common side effects. Some drugs may belong to several subgroups at once because their properties perform several functions. 

Other subgroups can also be added here, for example, drugs that reduce blood glucose or protect the kidneys. Their number is actually unlimited. We have added only the main ones to our list so as not to confuse you.

Main PEDs

 

Cycle support

  • Fertility support
  • Aromatase Inhibitors
  • Prolactin control
  • Blood pressure control 
  • Acne
  • Liver support
  • Lipids support
  • Hair loss

 

PCT

  • SERMs

 

MAIN PEDS

We have included two groups here. The first one includes various testosterones and the second one contains all the other Pads that are divided into subgroups. The choice of subgroups will occur depending on the athlete's goal, not each of the groups has a number of specific properties that determine the vector of action of each drug.

Testosterone base

Testosterone, being an important hormone, plays a vital role in male physiology and controls numerous processes. In addition, it is worth noting that, although testosterone can directly affect androgen receptors, a significant part of it is converted into other hormones, such as DHT and estradiol. These metabolites are even more active than the precursor hormone itself.

Maintaining an adequate level of estradiol is crucial for various body functions in men. Low estradiol levels can lead to osteoporosis, cardiovascular diseases, irritability, fertility problems and difficulties conceiving a child. Athletes often experience pain in joints and tendons in previously injured areas when the level of estradiol falls below the control values. Moreover, a low level of estradiol creates a greater problem than a high level of estradiol for the anabolism of the body in muscle tissue, since estradiol itself has anabolic properties.

DHT, another hormone derived from testosterone, binds strongly to androgen receptors in tissues, surpassing testosterone in its androgenic effects, despite its lower concentration. It regulates sexual behavior, erectile function and has a significant effect on the central nervous system. Insufficient levels of DHT negatively affect sexual function, reducing libido, contributing to erectile dysfunction and orgasm, and generally reducing sexual activity.

The problem arises when using anabolic steroids, as a result of which the testosterone level drops to zero within a few weeks. This triggers a cascade of reactions, including a decrease in the level of DHT, estradiol and other hormones necessary for the normal functioning of the body. Without including testosterone in the cycle, the body loses a lot of active hormones, since no anabolic steroid can completely replace all the functions of testosterone.

That is why you should use testosterone in any case, regardless of what anabolic steroids you use in addition. Using steroids without testosterone in a cycle can create a significant number of problems and side effects for you and reduce the effectiveness of the cycle or even reduce it to zero.

The dosage and form of testosterone will depend on the length of your cycle, the goal set and your level of training.

 Anabolic steroids and SARMs

Anabolic steroids commonly used alongside testosterone play a secondary role in achieving specific cycle goals. Testosterone serves as the foundation of any steroid cycle because it is the primary male hormone that supports essential bodily functions, such as libido, mood, energy levels, and muscle growth. During a cycle, testosterone is always used in exogenous form to maintain sufficient levels in the blood, as the body's natural production of testosterone is inevitably suppressed when using other steroids. However, to enhance results and meet specific goals—whether it's gaining muscle mass, improving definition, or increasing endurance—other anabolic steroids are often added to testosterone.

These steroids have various functions. For example, compounds like Nandrolone or Boldenone can amplify the anabolic effect of Testosterone, resulting in increased lean muscle mass and improved strength. Other steroids, such as Stanozolol or Trenbolone, help reduce water retention and enhance muscle density and definition.

Growth Hormone and GHR peptides

In addition to steroids, other performance-enhancing drugs (PEDs) such as growth hormone (HGH), IGF-1, and Growth Hormone-Releasing Peptides are often used. These substances can speed up recovery, boost fat-burning effects, improve skin condition, and increase protein synthesis, helping athletes achieve more pronounced results in bodybuilding or other sports.

Growth hormone (HGH), IGF-1, and peptides that increase growth hormone levels are widely used as performance-enhancing drugs (PEDs) due to their significant benefits in athletic performance and physique development.

HGH plays a crucial role in stimulating muscle growth, promoting fat loss, and improving recovery. It accelerates the regeneration of muscle tissue and connective tissues, making it highly valuable for athletes looking to recover faster from intense training and reduce the risk of injury. Additionally, HGH can improve skin elasticity and promote a youthful appearance, making it popular among those aiming for both aesthetic and athletic goals.

IIGF-1 (Insulin-like Growth Factor 1) is another powerful compound that works synergistically with HGH . It directly promotes cell growth and muscle hypertrophy by enhancing protein synthesis and nutrient absorption in muscle cells. IGF-1 is known for its ability to increase lean muscle mass, improve strength, and reduce body fat.

Peptides, such as GHRP-6, GHRP-2, and CJC-1295, stimulate the body's natural production of growth hormone, making them effective alternatives to exogenous HGH. These peptides offer the benefits of increased growth hormone release, leading to improved recovery, muscle growth, and fat metabolism, with fewer side effects compared to direct HGH use. Together, these compounds create a potent combination for enhancing athletic performance and achieving a well-defined physique.

Fat burners 

Clenbuterol, Yohimbine, and Semaglutide are often used as performance-enhancing drugs (PEDs) due to their unique effects on fat loss and metabolic enhancement.

Clenbuterol is a powerful beta-2 agonist that stimulates the central nervous system, increasing thermogenesis and fat oxidation. It helps athletes reduce body fat while preserving lean muscle mass, making it a popular choice during cutting phases. Additionally, Clenbuterol improves aerobic capacity by expanding the airways and enhancing oxygen uptake, which can lead to better endurance and performance in cardiovascular activities.

Yohimbine, a naturally occurring alpha-2 adrenergic receptor antagonist, also promotes fat loss by increasing adrenaline levels and mobilizing stored fat, particularly in stubborn areas like the abdomen. Yohimbine is most effective when used in a fasted state and is often combined with Clenbuterol to enhance the overall fat-burning effect.

Semaglutide, a GLP-1 receptor agonist, has gained popularity due to its ability to suppress appetite and regulate blood sugar levels. It helps athletes manage calorie intake and promotes steady fat loss without significant cravings, making it highly effective for those undergoing strict dietary regimens. Together, Clenbuterol, Yohimbine, and Semaglutide can provide powerful fat-burning effects and metabolic control, helping athletes achieve a leaner, more defined physique while optimizing their performance.

This subgroup also includes thyroid (T3 and T4) hormones that, acting on metabolism, also burn fat, as well as the peptide HGH Fragment 176-191, which is part of the amino acid chain of Growth Hormone responsible for fat burning.

Sexual health 

Cialyn(Tadalafil), Viagros(Sildenafil), and PT-141(Bremelanotide) are drugs commonly used to increase libido and improve erection.

Tadalafil and Sildenafil are phosphodiesterase-5 (PDE-5) inhibitors that help enhance erections by increasing blood flow to the genital area. They work by relaxing the smooth muscles of the blood vessels and dilating them, allowing for better blood flow and making erections stronger and longer-lasting. Tadalafilhas a longer duration of action (up to 36 hours), making it convenient for extended use, while Sildenafil works faster but for a shorter time (about 4-6 hours). These medications are effective in treating erectile dysfunction and can significantly enhance sexual performance.

PT-141(Bremelanotide) works differently—it does not directly affect blood flow but activates receptors in the brain responsible for sexual arousal and desire. Unlike Tadalafil and Sildenafil, PT-141 enhances libido by stimulating the nervous system, leading to increased sexual desire and motivation. This makes PT-141 particularly useful for people who experience a decrease in not only physical but also emotional desire.

All three drugs help improve sexual function, boost libido, and enhance erections, helping restore confidence in intimate life.

Injury support 

TB500 and BPC-157 are two powerful peptides commonly used by athletes to enhance recovery, promote healing, and support overall tissue repair. 

TB500 , a synthetic form of Thymosin Beta-4, is known for its ability to accelerate the repair of muscle, tendon, and ligament injuries. It works by promoting cell migration and angiogenesis (formation of new blood vessels), which improves blood flow and nutrient delivery to damaged tissues. This makes TB500 highly effective for athletes recovering from injuries or seeking to prevent overtraining by improving muscle recovery and flexibility.

BPC-157, a peptide derived from a protein found in the stomach, is highly regarded for its regenerative properties. It helps heal muscle, tendon, and ligament injuries by promoting collagen synthesis, reducing inflammation, and improving cell survival under stress. BPC-157 is particularly useful for athletes who experience chronic pain or are dealing with injuries that are slow to heal. Additionally, BPC-157 has shown potential in protecting organs from damage and promoting gut health, which can be beneficial for athletes under heavy physical stress. 

Together, TB500 and BPC-157 offer a potent combination for enhancing recovery, speeding up healing from injuries, and maintaining tissue integrity, making them invaluable tools for athletes looking to sustain their performance and longevity in sports.

CYCLE SUPPORT

Here we will talk about auxiliary drugs that are no less important than the anabolic steroids themselves, because they control the side effects of taking testosterone and protect against various kinds of troubles that can happen during your cycle. If you take testosterone  above therapeutic dosages, then most likely this list of drugs will be mandatory for its use.

This is a list of optional medications that are used only if you need additional protection from various side effects when they occur. We have given only part of this list, in fact, there are a huge number of drugs that solve possible problems on the cycle, and each of these PEDs should be used in a specific case.

Fertility support

HCG or HMG (gonadotropins) should be included in each of your cycles longer than 6 weeks. There are several reasons for this. Let's start with the fact that as you know, while taking anabolic steroids, our body turns off the production of its own testosterone completely. After your cycle, you must restore it with PCT.

So, when using gonadotropins during your cycle, it helps to restore your testosterone mush faster, which means that with a normal testosterone level, you will be able to maintain the gained result, and also not fall into the “emotional hole” that often happens at a low-level testosterone. It works in such a way that gonadotropins are a hormones that even during a cycle of steroids instructs your testicles to produce their own testosterone . Although your hypothalamus and pituitary gland will not be involved in this process, your testicles will work and that will help to avoid atrophy. That is, your testicles by the time of PCT will be ready to increase testosterone without delay.

There is also another reason why HCG or HMG should be used, especially during the long cycles. The fact is that anabolic steroids not only ‘turn off’ the production of their own testosterone, but also in the same way affect the cessation of the production of other steroid hormones such as pregnenolone, progesterone, aldosterone, DHEA, and others. In this chain, each of these hormones has its own important role and when you use the testosterone during your cycle, the process of producing these hormones is also disrupted. As a result, your body is left without a hormones it needs. Using gonadotropins – you save the entire chain of prohormones synthesis of steroid genesis. Some of the hormones that are created in this cascade of reactions are neurosteroids which have a positive effect on your mood, behavior, and libido.

  • Progesterone reduces the risk of prostatic hyperplasia and tumor processes, takes part in the functioning of the nervous system, helps to maintain normal levels of female sex hormones, strengthens bone tissue, normalizes thyroid function, and has a number of other important properties. 
  • Pregnenolone is important for brain function, due to its deficiency, memory and cognitive abilities deteriorate.
  • DHEA - the action of this hormone is not fully understood, but there is an evidence that indicates its widespread influence in the body. DHEA is crucial for the cardiovascular system and central nervous system, osteoporosis, weakening of the immune system.

In order to prevent testicular atrophy, as well as to resume the steroidogenesis of your adrenal glands, it is necessary to take:

  •  HCG during the entire cycle from 500 to 2500 IU per week, depending on the specific case. We recommend using 1000 IU per week. This dosage is average and suitable for most people. 
  • HMG dosage is 75-150 IU 2-3 times per week.

There is a misconception that gonadotropins should be taken during PCT. This is not true because the stimulation of your testicles themselves by imitation the action of hormones such as LH and FSH.

The actual triggering process for HPTA must begin in your pituitary gland and will be accelerated by drugs such as Clomiphene and Tamoxifen. HCG should be used during the cycle to keep your testicles from atrophying so that by the time of PCT they can quickly respond to pituitary stimulation with testosterone production. If this is not done, then you will have to wait a very long time until this mechanism starts itself after many months of “vacation”.

Aromatase inhibitors

Using Testosterone, we inevitably encounter the effects of aromatization. Aromatase is an enzyme in the human body that may convert testosterone into estradiol. In turn, estrogens have both positive and negative effects on the body. In case of excess aromatization, the athlete gets estrogenic side effects, such as: a decrease in the psychoemotional mood, gynecomastia, an increase in female-type fat deposits, edema, decreased libido, and others. But never trust your own feelings when you can find out the objective truth: check your hormones with a blood test. Only with the help of an estradiol analysis will you be able to understand its real level.

Aromatase inhibitors are drugs that will help reduce the level of estradiol. You can choose which drug to use - usually it is Anastrozole, Exemestane or Letrozole. In rare cases, several different drugs are used if the level of aromatization is too high. Dosages will always depend on your estradiol level. Not to reduce estradiol is a big mistake that will affect your well-being and results. The most popular drugs in this group are Anastrozole, Exemestane , Letrozole.

Prolactin control

Among anabolic steroids, there are drugs that can increase such a hormone as prolactin - 19nortestosterones (Nandrolone, Trenbolone and Trestolone) . An increase in prolactin above the reference values threatens the male body with significant negative consequences: fluid retention, decreased libido and worsening of erection, infertility, a decrease in secondary sexual characteristics, an increase in female-type mammary glands (gynecomastia) and possible discharge from them.

High prolactin levels worsen your cholesterol levels, impair lipid metabolism, which increases the chance of obesity. There is also evidence of an increased risk of type 2 diabetes. In the long term, it leads to a decrease in bone mineral density. Your bones become more brittle. Many athletes during elevated prolactin levels complain of bad mood, apathy, nervousness and anxiety, irritability, emotional instability and even psychosis. Cases of depression, high fatigue, memory impairment, poor concentration, as well as pain in the heart area are not uncommon. Various vegetative disorders are also possible.

Always monitor your blood counts and have a drug like Cabergoline on hand if you are going to use Nandrolone or other drugs that increase prolactin. Increased prolactin should be reduced with Cabergoline . This drug will help you to reduce prolactin levels. You should take the drug after you know your prolactin level only.

Blood pressure control 

Telmisartan and Nebivolol are two medications that athletes using anabolic steroids can incorporate to maintain their health, particularly in protecting the cardiovascular system. These drugs help control blood pressure and reduce the strain on the heart, which can be critically important when using steroids that may cause hypertension and other cardiovascular complications.

Telmisartan is an angiotensin II receptor antagonist that helps lower blood pressure by relaxing blood vessels. It also has additional metabolic benefits, such as improving insulin sensitivity and reducing inflammation. These effects are especially valuable for athletes on steroids, as anabolic compounds can elevate blood pressure and contribute to the accumulation of visceral fat. Telmisartan can help mitigate such risks by supporting heart and vascular health throughout the cycle.

Nebivolol is a selective beta-blocker that not only lowers blood pressure but also stimulates the release of nitric oxide, promoting vasodilation and improving circulation. For athletes, this means not only protecting the heart from overload but also enhancing blood flow to muscles, which can positively impact recovery and performance. Additionally, Nebivolol helps prevent excessive strain on the heart caused by elevated testosterone levels and other steroids, making it beneficial for maintaining cardiovascular health during anabolic steroid cycles.

While other medications, such as Losartan or Bisoprolol, could also be used for these purposes, the focus on Telmisartan and Nebivolol is due to their additional advantages. Telmisartan, in addition to lowering blood pressure, positively affects metabolism and fat loss, while Nebivolol improves vascular function through the stimulation of nitric oxide release. This makes them particularly appealing to athletes aiming to not only protect their cardiovascular system but also optimize physical condition and athletic performance.

Acne

Isotretinoin (Accutane) is a potent medication commonly used by athletes during steroid cycles to manage and treat severe acne. One of the side effects of anabolic steroid use is an increase in oil production in the skin, which can lead to acne outbreaks, especially on the face, back, and shoulders. Isotretinoin works by reducing the size of the sebaceous glands, decreasing oil production, and helping to prevent clogged pores and the resulting acne.

For athletes, controlling acne is not only important for appearance but also for comfort, especially during intense training where sweating can exacerbate skin issues. However, the use of Isotretinoin must be approached with caution, as it is a powerful drug with significant side effects, including dryness of the skin, lips, and eyes, increased sensitivity to the sun, and potential liver strain. Given that anabolic steroids can also impact liver function, athletes using Isotretinoin  should closely monitor their liver health with regular blood tests and consult with a healthcare professional to ensure safe usage.

Isotretinoin is usually reserved for athletes who experience persistent or severe acne that cannot be controlled with topical treatments or milder medications. When used responsibly and under medical supervision, it can be an effective solution for managing steroid-induced acne, allowing athletes to maintain clearer skin throughout their cycles.

Liver support

Anabolic steroids, especially in oral form, can put significant stress on the liver due to their hepatotoxic nature. Oral anabolic steroids are often methylated to survive the first-pass metabolism through the liver, which increases their potency but also raises the risk of liver strain and potential damage. This makes the liver particularly vulnerable during steroid cycles, and as a result, athletes and bodybuilders are encouraged to incorporate hepatoprotectors—supplements or medications that support liver health. Using hepatoprotectors such as SAMe, TUDCA, NAC, and TAD600 during steroid cycles can help mitigate liver damage, promote detoxification, and support overall liver function, allowing athletes to safeguard their health while pursuing their performance goals.

S-Adenosyl methionine (SAMe) is a naturally occurring compound that plays a vital role in liver detoxification and methylation processes. SAMe supports the liver's ability to regenerate cells and reduce inflammation, making it a valuable supplement for athletes looking to prevent liver damage during steroid cycles. SAMe also has additional benefits, such as mood stabilization and joint support, which can be particularly helpful during intense training periods.

TUDCA (Tauroursodeoxycholic Acid) is a bile acid derivative that is highly effective at protecting the liver from damage, particularly from cholestasis (bile flow blockages), which can occur with oral steroids. TUDCA improves liver function by supporting bile flow and reducing cellular stress in the liver, making it a go-to supplement for athletes seeking enhanced liver protection.

NAC (N-Acetyl Cysteine) is a powerful antioxidant that boosts glutathione production, one of the body’s most important antioxidants. NAC helps neutralize free radicals and reduces oxidative stress on the liver, protecting it from damage caused by steroid use. Its ability to support liver detoxification and repair makes NAC an essential part of any athlete’s supplement regimen during steroid cycles.

TAD600 (injectable Glutathione) is another potent antioxidant that directly detoxifies the liver and helps maintain its health during anabolic steroid use. Glutathione is known for its ability to protect cells from oxidative stress, support liver function, and enhance overall immune system health. Athletes often use TAD600 as a more aggressive method of liver protection, particularly during heavy or extended steroid cycles.

Together, SAMe, TUDCA, NAC, and TAD600 provide comprehensive liver protection, supporting detoxification, reducing oxidative stress, and helping athletes maintain their health during periods of increased liver strain from steroid use. By integrating these supplements, athletes can mitigate many of the risks associated with anabolic steroid cycles, ensuring better long-term health and performance.

Lipids support 

Anabolic steroid use can negatively impact cholesterol levels and overall lipid profiles, often leading to decreased HDL ("good" cholesterol) and increased LDL ("bad" cholesterol), which can elevate the risk of cardiovascular diseases. Athletes and bodybuilders looking to counter these effects often incorporate cholesterol-lowering and lipid-improving supplements into their cycles. Natural compounds such as Niacin, Berberine, and Astragalus are popular for their ability to improve cholesterol metabolism, reduce inflammation, and promote cardiovascular health. Niacin, for example, is known to increase HDL levels, while Berberine improves insulin sensitivity and reduces LDL levels.

However, for those seeking more potent cholesterol management, Pitavastatin and Ezetimibe are among the most effective pharmaceutical options. Pitavastatin is a statin that works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol production in the liver. It is particularly effective at reducing LDL levels and improving overall lipid profiles, with a lower risk of muscle-related side effects compared to other statins. Pitavastatin's ability to improve cardiovascular health while minimizing adverse effects makes it an ideal choice for athletes who need to control cholesterol without sacrificing performance.

Ezetimibe, on the other hand, works by blocking the absorption of cholesterol in the intestines, reducing the amount of cholesterol entering the bloodstream. It is often used in combination with statins for a more comprehensive approach to lowering LDL levels. Ezetimibe is highly effective at reducing cholesterol levels without affecting liver enzymes or muscle function, making it an excellent option for steroid users who want to manage their lipid profiles without the typical side effects associated with more aggressive medications. Together, Pitavastatin and Ezetimibe provide a powerful combination for maintaining heart health and managing cholesterol levels during steroid cycles.

Hair loss

Anabolic steroid use can accelerate hair loss, particularly in individuals genetically predisposed to male pattern baldness. This is often caused by the conversion of testosterone to dihydrotestosterone (DHT), a potent androgen that shrinks hair follicles and contributes to hair thinning and loss. To mitigate this side effect, many athletes and bodybuilders incorporate Finasteride into their steroid cycles. Finasteride works by inhibiting the enzyme 5-alpha reductase, which converts testosterone into DHT, thereby reducing the amount of DHT in the scalp and slowing hair loss.

In addition to Finasteride , other treatments like Minoxidil (a topical solution) and Ketoconazole shampoos are often used to promote hair growth and protect hair follicles during cycles. These solutions can help maintain scalp health, stimulate hair growth, and reduce the shedding that might occur during steroid use. Incorporating these treatments into a steroid cycle can help athletes minimize the risk of hair loss while focusing on their performance goals.

POST-CYCLE THERAPY (PCT)

The main task is to encourage the body to produce its own testosterone after discontinuing all medications. The task is not quite simple, since during the course the production of your own testosterone is completely suspended. Usually, even after long courses, testosterone will recover naturally sooner or later, but it can take a very long time. During this time, you will not only lose all your results, but you may also have time to plunge into unpleasant psychological states due to the complete absence of the main male hormone - testosterone . Prolonged absence of testosterone is not only a psychological discomfort, but also generally unhealthy for your body, because at this moment, according to the medical diagnosis, you are in a state of hypogonadism.

If the PCT was not carried out at all, the athlete may face many problems that will be associated with low testosterone levels. The problems of low testosterone levels in your blood are both limitations for your athletic performance, and a blow to your psychological state and many body systems. We strongly recommend that you take the post-course therapy with the utmost seriousness, perhaps that process is even more important than the steroid cycle itself. If you have made a medical intervention in your body and disturbed the natural balance in favor of increasing androgens in your blood, then the most correct solution would be to bring everything back to its original values as soon as possible with the same medical intervention when your androgens are too low.

It is worth noting that the better and faster you do PCT, the faster you will recover and the less time you will be in uncomfortable states in every sense. Below are possible temporary unpleasant effects during PCT. In the absence of PCT, these effects can be more pronounced and significantly longer.

Usually, the PCT scheme includes the use of SERM group drugs. For the best effect, in most cases, Tamoxifen or Raloxifene is used together with Clomiphene or Enclomiphene, less often used separately. The dosage will depend on the duration of the cycle, dosages and medications that you have used.